Tirzepatide

What Is Tirzepatide?
Tirzepatide is a synthetic peptide engineered to activate both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor. This dual mechanism distinguishes it from GLP-1 receptor agonists alone and has been the focus of extensive clinical investigation.
Large randomized studies have evaluated tirzepatide across metabolic disorders and cardiovascular risk factors, making it one of the most comprehensively studied dual incretin therapies available. (Jastreboff AM et al., NEJM, 2022; Frias JP et al., NEJM, 2021.)
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Current Research
Research has examined tirzepatide's effects on incretin biology, glucose metabolism, energy balance, and cardiometabolic health.
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